Spatial Heterogeneity in Drug Concentrations Can Facilitate the Emergence of Resistance to Cancer Therapy

Open Access

Peer-reviewed

Research Article

Feng Fu ,

* E-mail: fufeng@gmail.com

Affiliation Theoretical Biology Group, Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland
⨯
Martin A. Nowak,

Affiliation Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Sebastian Bonhoeffer

Affiliation Theoretical Biology Group, Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland
⨯

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Cancer treatment
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Metastasis
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Point mutation
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Malignant tumors
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Cancers and neoplasms
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Cancer cell migration
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Breast cancer
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Drug therapy
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