Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies

Federica Lombardi; Kalyan Golla; Darren J. Fitzpatrick; Fergal P. Casey; Niamh Moran; Denis C. Shields

doi:10.1371/journal.pcbi.1004119

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Peer-reviewed

Research Article

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies

Federica Lombardi,

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
⨯
Kalyan Golla,

Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
⨯
Darren J. Fitzpatrick,

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
⨯
Fergal P. Casey,

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
⨯
Niamh Moran ,

* E-mail: nmoran@rcsi.ie (NM); Denis.shields@ucd.ie (DCS)

Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
⨯
Denis C. Shields

* E-mail: nmoran@rcsi.ie (NM); Denis.shields@ucd.ie (DCS)

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
⨯

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies

Federica Lombardi,
Kalyan Golla,
Darren J. Fitzpatrick,
Fergal P. Casey,
Niamh Moran,
Denis C. Shields

Published: April 15, 2015
https://doi.org/10.1371/journal.pcbi.1004119

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