Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells

Lu Chen; Lei Du-Cuny; Sylvestor Moses; Sabrina Dumas; Zuohe Song; Abdol Hossein Rezaeian; Hui-Kuan Lin; Emmanuelle J. Meuillet; Shuxing Zhang

doi:10.1371/journal.pcbi.1004021

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Peer-reviewed

Research Article

Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells

Lu Chen,

Affiliation Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Lei Du-Cuny,

Affiliation Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Sylvestor Moses,

Affiliation Departments of Nutritional Sciences and Molecular and Cellular Biology, the University of Arizona Cancer Center, Tucson, Arizona, United States of America
⨯
Sabrina Dumas,

Affiliation Departments of Nutritional Sciences and Molecular and Cellular Biology, the University of Arizona Cancer Center, Tucson, Arizona, United States of America
⨯
Zuohe Song,

Affiliation Departments of Nutritional Sciences and Molecular and Cellular Biology, the University of Arizona Cancer Center, Tucson, Arizona, United States of America
⨯
Abdol Hossein Rezaeian,

Affiliation Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Hui-Kuan Lin,

Affiliation Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Emmanuelle J. Meuillet ,

* E-mail: emeuillet@azcc.arizona.edu (EJM); shuzhang@mdanderson.org (SZ)

Affiliation Departments of Nutritional Sciences and Molecular and Cellular Biology, the University of Arizona Cancer Center, Tucson, Arizona, United States of America
⨯
Shuxing Zhang

* E-mail: emeuillet@azcc.arizona.edu (EJM); shuzhang@mdanderson.org (SZ)

Affiliation Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯

Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells

Lu Chen,
Lei Du-Cuny,
Sylvestor Moses,
Sabrina Dumas,
Zuohe Song,
Abdol Hossein Rezaeian,
Hui-Kuan Lin,
Emmanuelle J. Meuillet,
Shuxing Zhang

Published: January 8, 2015
https://doi.org/10.1371/journal.pcbi.1004021

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