A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

• Marnix H. Medema ,

  Contributed equally to this work with: Marnix H. Medema, Peter Cimermancic

  Current address: Max Planck Institute for Marine Microbiology, Bremen, Germany

  Affiliations Department of Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands, Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands

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• Peter Cimermancic ,

  Contributed equally to this work with: Marnix H. Medema, Peter Cimermancic

  Affiliations Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, San Francisco, California, United States of America

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• Andrej Sali,

  Affiliations Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

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• Eriko Takano,

  Affiliation Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

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• Michael A. Fischbach

  * E-mail: fischbach@fischbachgroup.org

  Affiliations Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, San Francisco, California, United States of America

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