Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

• Thomas R. Caulfield ,

  Contributed equally to this work with: Thomas R. Caulfield, Fabienne C. Fiesel

  * E-mail: Caulfield.Thomas@mayo.edu (TRC); Springer.Wolfdieter@mayo.edu (WS)

  Affiliation Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America

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• Fabienne C. Fiesel ,

  Contributed equally to this work with: Thomas R. Caulfield, Fabienne C. Fiesel

  Affiliation Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America

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• Elisabeth L. Moussaud-Lamodière,

  Affiliation Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America

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• Daniel F. A. R. Dourado,

  Affiliation Department of Cell & Molecular Biology, Computational & Systems Biology, Uppsala University, Uppsala, Sweden

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• Samuel C. Flores,

  Affiliation Department of Cell & Molecular Biology, Computational & Systems Biology, Uppsala University, Uppsala, Sweden

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• Wolfdieter Springer

  * E-mail: Caulfield.Thomas@mayo.edu (TRC); Springer.Wolfdieter@mayo.edu (WS)

  Affiliations Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America, Mayo Graduate School, Neurobiology of Disease, Mayo Clinic, Jacksonville, Florida, United States of America

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