Examining Variable Domain Orientations in Antigen Receptors Gives Insight into TCR-Like Antibody Design

Open Access

Peer-reviewed

Research Article

James Dunbar,

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯
Bernhard Knapp,

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯
Angelika Fuchs,

Affiliation F. Hoffmann-La Roche Ltd, Pharma Research and Early Development, Informatics, Penzberg, Germany
⨯
Jiye Shi,

Affiliation Informatics, UCB Pharma, Slough, United Kingdom
⨯
Charlotte M. Deane

* E-mail: deane@stats.ox.ac.uk

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯

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T cell receptors
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Antibodies
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Major histocompatibility complex
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T cells
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Antigenic variation
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Protein engineering
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Antigen processing and recognition
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Immune system
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