Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products

Marnix H. Medema; Yared Paalvast; Don D. Nguyen; Alexey Melnik; Pieter C. Dorrestein; Eriko Takano; Rainer Breitling

doi:10.1371/journal.pcbi.1003822

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Peer-reviewed

Research Article

Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products

Marnix H. Medema ,

* E-mail: marnixmedema@gmail.com

Current address: Microbial Genomics and Bioinformatics Research Group, Max Planck Institute for Marine Microbiology, Bremen, Germany

Affiliations Department of Microbial Physiology, University of Groningen, Groningen, The Netherlands, Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands
⨯
Yared Paalvast,

Affiliations Department of Microbial Physiology, University of Groningen, Groningen, The Netherlands, Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands
⨯
Don D. Nguyen,

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences and Departments of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America
⨯
Alexey Melnik,

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences and Departments of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America
⨯
Pieter C. Dorrestein,

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences and Departments of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America
⨯
Eriko Takano,

Affiliations Department of Microbial Physiology, University of Groningen, Groningen, The Netherlands, Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Rainer Breitling

Affiliations Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands, Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯

Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products

Marnix H. Medema,
Yared Paalvast,
Don D. Nguyen,
Alexey Melnik,
Pieter C. Dorrestein,
Eriko Takano,
Rainer Breitling

Published: September 4, 2014
https://doi.org/10.1371/journal.pcbi.1003822

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Peptide synthesis
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