The Free Energy Profile of Tubulin Straight-Bent Conformational Changes, with Implications for Microtubule Assembly and Drug Discovery

• Lili X. Peng ,

  Contributed equally to this work with: Lili X. Peng, Monica T. Hsu

  Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

  ⨯
• Monica T. Hsu ,

  Contributed equally to this work with: Lili X. Peng, Monica T. Hsu

  Affiliation Graduate Group in Biophysics, University of California, San Francisco, San Francisco, California, United States of America

  ⨯
• Massimiliano Bonomi,

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America

  ⨯
• David A. Agard,

  Affiliation Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

  ⨯
• Matthew P. Jacobson

  * E-mail: matt.jacobson@ucsf.edu

  Affiliations Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

  ⨯