Detection of Mixed Infection from Bacterial Whole Genome Sequence Data Allows Assessment of Its Role in Clostridium difficile Transmission

David W. Eyre; Madeleine L. Cule; David Griffiths; Derrick W. Crook; Tim E. A. Peto; A. Sarah Walker; Daniel J. Wilson

doi:10.1371/journal.pcbi.1003059

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Open Access

Peer-reviewed

Research Article

Detection of Mixed Infection from Bacterial Whole Genome Sequence Data Allows Assessment of Its Role in Clostridium difficile Transmission

David W. Eyre ,

* E-mail: david.eyre@ndm.ox.ac.uk

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Madeleine L. Cule,

Affiliations NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯
David Griffiths,

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯
Derrick W. Crook,

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯
Tim E. A. Peto,

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯
A. Sarah Walker ,

Contributed equally to this work with: A. Sarah Walker, Daniel J. Wilson

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom, Medical Research Council, Clinical Trials Unit, London, United Kingdom
⨯
Daniel J. Wilson

Contributed equally to this work with: A. Sarah Walker, Daniel J. Wilson

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
⨯

Detection of Mixed Infection from Bacterial Whole Genome Sequence Data Allows Assessment of Its Role in Clostridium difficile Transmission

David W. Eyre,
Madeleine L. Cule,
David Griffiths,
Derrick W. Crook,
Tim E. A. Peto,
A. Sarah Walker,
Daniel J. Wilson

Published: May 2, 2013
https://doi.org/10.1371/journal.pcbi.1003059

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