Mutational Analysis of the High-Affinity Zinc Binding Site Validates a Refined Human Dopamine Transporter Homology Model

Open Access

Peer-reviewed

Research Article

Thomas Stockner,

Affiliation Center of Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna, Vienna, Austria
⨯
Therese R. Montgomery,

Affiliation Center of Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna, Vienna, Austria
⨯
Oliver Kudlacek,

Affiliation Center of Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna, Vienna, Austria
⨯
Rene Weissensteiner,

Affiliation Department of Medicinal Chemistry, University of Vienna, Vienna, Austria
⨯
Gerhard F. Ecker,

Affiliation Department of Medicinal Chemistry, University of Vienna, Vienna, Austria
⨯
Michael Freissmuth,

Affiliation Center of Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna, Vienna, Austria
⨯
Harald H. Sitte

* E-mail: harald.sitte@meduniwien.ac.at

Affiliation Center of Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna, Vienna, Austria
⨯

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Chlorides
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Zinc
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Biochemical simulations
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Cysteine
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Histidine
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Salt bridges
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Dopamine transporters
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Crystal structure
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