Animal Cell Differentiation Patterns Suppress Somatic Evolution

Open Access

Peer-reviewed

Research Article

John W Pepper ,

*To whom correspondence should be addressed. E-mail: jpepper1@email.arizona.edu

Affiliations Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America, The Santa Fe Institute, Santa Fe, New Mexico, United States of America
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Kathleen Sprouffske,

Affiliations Genomics and Computational Biology Program, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Systems Biology Division, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Carlo C Maley

Affiliation Systems Biology Division, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
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Cell differentiation
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Stem cells
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Cell cycle and cell division
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Death rates
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Organismal evolution
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Carcinogenesis
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Somatic mutation
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Gastrointestinal cancers
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