Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays

• Rameen Beroukhim ,

  Contributed equally to this work with: Rameen Beroukhim, Ming Lin

  Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Ming Lin ,

  Contributed equally to this work with: Rameen Beroukhim, Ming Lin

  Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• Yuhyun Park,

  Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• Ke Hao,

  Affiliation Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• Xiaojun Zhao,

  Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Levi A Garraway,

  Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Edward A Fox,

  Affiliation Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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• Ephraim P Hochberg,

  Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Ingo K Mellinghoff,

  Affiliation Departments of Medicine and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Matthias D Hofer,

  Affiliations Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Aurelien Descazeaud,

  Affiliations Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Mark A Rubin,

  Affiliations Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Matthew Meyerson,

  Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Wing Hung Wong,

  Affiliation Department of Statistics, Stanford University, Stanford, California, United States of America

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• William R Sellers ,

  *To whom correspondence should be addressed. E-mail: william.sellers@novartis.com (WRS); cli@hsph.harvard.edu (CL)

  ¤ Current address: Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

  Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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•  [ ... ],
• Cheng Li

  *To whom correspondence should be addressed. E-mail: william.sellers@novartis.com (WRS); cli@hsph.harvard.edu (CL)

  Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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