Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Thomas LaFramboise; Barbara A Weir; Xiaojun Zhao; Rameen Beroukhim; Cheng Li; David Harrington; William R Sellers; Matthew Meyerson

doi:10.1371/journal.pcbi.0010065

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Open Access

Peer-reviewed

Research Article

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Thomas LaFramboise,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Barbara A Weir,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
⨯
Xiaojun Zhao,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
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Rameen Beroukhim,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Cheng Li,

Affiliation Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, United States of America
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David Harrington,

Affiliation Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, United States of America
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William R Sellers,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Matthew Meyerson

*To whom correspondence should be addressed. E-mail: matthew_meyerson@dfci.harvard.edu

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Thomas LaFramboise,
Barbara A Weir,
Xiaojun Zhao,
Rameen Beroukhim,
Cheng Li,
David Harrington,
William R Sellers,
Matthew Meyerson

Published: November 25, 2005
https://doi.org/10.1371/journal.pcbi.0010065

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24 May 2011
15:16 GMT
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Software availability update Posted by PLOS_CompBiol on 24 May 2011 at 15:16 GMT

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Single nucleotide polymorphisms
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Lung and intrathoracic tumors
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Polymerase chain reaction
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Homozygosity
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Cancer genomics
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Haplotypes
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Alleles
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Heterozygosity
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