Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Thomas LaFramboise; Barbara A Weir; Xiaojun Zhao; Rameen Beroukhim; Cheng Li; David Harrington; William R Sellers; Matthew Meyerson

doi:10.1371/journal.pcbi.0010065

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Peer-reviewed

Research Article

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Thomas LaFramboise,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Barbara A Weir,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
⨯
Xiaojun Zhao,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
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Rameen Beroukhim,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Cheng Li,

Affiliation Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, United States of America
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David Harrington,

Affiliation Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, United States of America
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William R Sellers,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America , Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Matthew Meyerson

*To whom correspondence should be addressed. E-mail: matthew_meyerson@dfci.harvard.edu

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America , Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Thomas LaFramboise,
Barbara A Weir,
Xiaojun Zhao,
Rameen Beroukhim,
Cheng Li,
David Harrington,
William R Sellers,
Matthew Meyerson

Published: November 25, 2005
https://doi.org/10.1371/journal.pcbi.0010065

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24 May 2011
15:16 GMT
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Software availability update Posted by PLOS_CompBiol on 24 May 2011 at 15:16 GMT

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Single nucleotide polymorphisms
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Lung and intrathoracic tumors
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Polymerase chain reaction
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Homozygosity
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Cancer genomics
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Haplotypes
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Alleles
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Heterozygosity
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