Reader Comments

Post a new comment on this article

Regarding number of enzymes of NCI60 cancer data

Posted by PavanIITM on 27 Oct 2020 at 18:14 GMT

Hi,
After processing the dataset, 1325 enzymes were obtained for the NCI60 data as shown in the manuscript. But total number of enzymes in all the 26 clusters goes around 1802 enzymes as shown in the supplementary text (which is the total enzymes in the recon2.2 model). So, should we need to do clustering for missing data too, if so all the missing data should be in a single cluster or am i missing something.
Thanks in advance..

No competing interests declared.

RE: Regarding number of enzymes of NCI60 cancer data

cjjoshi replied to PavanIITM on 28 Oct 2020 at 08:07 GMT

Hi PavanIITM,
Thanks for pointing that out. This is a typo and is a leftover from a previous iteration of the paper which used a different dataset. "1325 enzymes (4133 reactions)" should actually be "1802 enzymes (4738 reactions)". If interested, you can find analysis on that dataset (CellMiner) in an earlier version of biorxiv submission (https://www.biorxiv.org/c...). If you wish to use StanDep, please see the tutorial here on Github (https://github.com/LewisL...). Further, if there are any questions on using StanDep, please feel free to reach out to me at cjjoshi@ucsd.edu.
Cheers,
Chintan

No competing interests declared.