A zero-parameter first-principles gate framework for full-length TP53 missense variant interpretation

Masamichi Iizumi

doi:10.1371/journal.pcbi.1014168

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Open Access

Peer-reviewed

Research Article

A zero-parameter first-principles gate framework for full-length TP53 missense variant interpretation

Masamichi Iizumi

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft

* E-mail: m.iizumi@miosync.email

Affiliation Miosync, Inc., Tokyo, Japan

https://orcid.org/0009-0007-0755-403X

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A zero-parameter first-principles gate framework for full-length TP53 missense variant interpretation

Masamichi Iizumi

Published: June 11, 2026
https://doi.org/10.1371/journal.pcbi.1014168

About the Authors

Masamichi Iizumi

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft

* E-mail: m.iizumi@miosync.email

Affiliation Miosync, Inc., Tokyo, Japan

https://orcid.org/0009-0007-0755-403X

Competing Interests

The author declares no competing interests.

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Logic circuits
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Proline
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Glycine
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Chemical disruption
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Protein structure
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Sequence motif analysis
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Pathogens
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