Simultaneously determining regional heterogeneity and connection directionality from neural activity and symmetric connection

Jiawen Chang; Zhuda Yang; Changsong Zhou

doi:10.1371/journal.pcbi.1013612

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Open Access

Peer-reviewed

Research Article

Simultaneously determining regional heterogeneity and connection directionality from neural activity and symmetric connection

Jiawen Chang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Centre for Nonlinear Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong
⨯
Zhuda Yang,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Centre for Nonlinear Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong
⨯
Changsong Zhou

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: cszhou@hkbu.edu.hk

Affiliations Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Centre for Nonlinear Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Life Science Imaging Centre, Hong Kong Baptist University, Kowloon Tong, Hong Kong

https://orcid.org/0000-0002-4130-0216

⨯

Simultaneously determining regional heterogeneity and connection directionality from neural activity and symmetric connection

Jiawen Chang,
Zhuda Yang,
Changsong Zhou

Published: October 23, 2025
https://doi.org/10.1371/journal.pcbi.1013612

About the Authors

Jiawen Chang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Centre for Nonlinear Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong

Zhuda Yang

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Centre for Nonlinear Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong

Changsong Zhou

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: cszhou@hkbu.edu.hk

Affiliations Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Centre for Nonlinear Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Life Science Imaging Centre, Hong Kong Baptist University, Kowloon Tong, Hong Kong

https://orcid.org/0000-0002-4130-0216

Competing Interests

The authors have declared that no competing interests exist.

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Neural networks
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Macaque
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Network analysis
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Functional magnetic resonance imaging
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Covariance
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Nonlinear dynamics
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White noise
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Neurons
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