Assessing parameter identifiability of a hemodynamics PDE model using spectral surrogates and dimension reduction

Mitchel J. Colebank

doi:10.1371/journal.pcbi.1013553

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Peer-reviewed

Research Article

Assessing parameter identifiability of a hemodynamics PDE model using spectral surrogates and dimension reduction

Mitchel J. Colebank

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mjcolebank@sc.edu

Affiliations Department of Mathematics, University of South Carolina, Columbia, South Carolina, United States of America, Department of Biomedical Engineering, University of South Carolina, Columbia, South Carolina, United States of America

https://orcid.org/0000-0002-2294-9124

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Assessing parameter identifiability of a hemodynamics PDE model using spectral surrogates and dimension reduction

Mitchel J. Colebank

Published: October 9, 2025
https://doi.org/10.1371/journal.pcbi.1013553

About the Authors

Mitchel J. Colebank

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mjcolebank@sc.edu

Affiliations Department of Mathematics, University of South Carolina, Columbia, South Carolina, United States of America, Department of Biomedical Engineering, University of South Carolina, Columbia, South Carolina, United States of America

https://orcid.org/0000-0002-2294-9124

Competing Interests

The authors have declared that no competing interests exist.

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Polynomials
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Experimental design
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Recombinase polymerase amplification
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Principal component analysis
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Hemodynamics
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Stiffness
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Diastole
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Systole
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