Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1)

Rym Ben Boubaker; Daniel Henrion; Marie Chabbert

doi:10.1371/journal.pcbi.1012559

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Open Access

Peer-reviewed

Research Article

Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1)

Rym Ben Boubaker,

Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation UMR CNRS 6015 –INSERM 1083, Laboratoire MITOVASC, Université d’Angers, Angers, France

https://orcid.org/0000-0002-3329-1831

⨯
Daniel Henrion,

Roles Funding acquisition, Writing – review & editing

Affiliation UMR CNRS 6015 –INSERM 1083, Laboratoire MITOVASC, Université d’Angers, Angers, France
⨯
Marie Chabbert

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft

* E-mail: marie.chabbert@univ-angers.fr

Affiliation UMR CNRS 6015 –INSERM 1083, Laboratoire MITOVASC, Université d’Angers, Angers, France

https://orcid.org/0000-0002-5182-0987

⨯

Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1)

Rym Ben Boubaker,
Daniel Henrion,
Marie Chabbert

Published: November 13, 2024
https://doi.org/10.1371/journal.pcbi.1012559

About the Authors

Rym Ben Boubaker

Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation UMR CNRS 6015 –INSERM 1083, Laboratoire MITOVASC, Université d’Angers, Angers, France

https://orcid.org/0000-0002-3329-1831

Daniel Henrion

Roles Funding acquisition, Writing – review & editing

Affiliation UMR CNRS 6015 –INSERM 1083, Laboratoire MITOVASC, Université d’Angers, Angers, France

Marie Chabbert

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft

* E-mail: marie.chabbert@univ-angers.fr

Affiliation UMR CNRS 6015 –INSERM 1083, Laboratoire MITOVASC, Université d’Angers, Angers, France

https://orcid.org/0000-0002-5182-0987

Competing Interests

The authors have declared that no competing interests exist.

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Lipids
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Surface tension
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Biochemical simulations
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Molecular dynamics
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Intracellular receptors
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Biophysical simulations
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Mechanical stress
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G protein coupled receptors
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