About the Authors

Jared Adolf-Bryfogle

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

jadolfbr@gmail.com (JAB); schief@scripps.edu (WRS)

Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, United States of America, Institute for Protein Innovation, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Jason W. Labonte

Roles Conceptualization, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation Department of Chemistry & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

John C. Kraft

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

Maxim Shapovalov

Roles Data curation, Formal analysis, Software, Writing – original draft, Writing – review & editing

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

Sebastian Raemisch

Roles Conceptualization, Investigation, Methodology, Software

Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, United States of America

Thomas Lütteke

Roles Data curation, Methodology, Software

Affiliation Institute of Veterinary Physiology and Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany

Frank DiMaio

Roles Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

Christopher D. Bahl

Roles Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliations Institute for Protein Innovation, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Jesper Pallesen

Roles Conceptualization, Validation

Affiliations Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, United States of America, Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Neil P. King

Roles Conceptualization, Funding acquisition, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing

Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

Jeffrey J. Gray

Roles Funding acquisition, Project administration, Resources, Software, Writing – original draft, Writing – review & editing

Affiliation Department of Chemistry & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

Daniel W. Kulp

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America

William R. Schief

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

jadolfbr@gmail.com (JAB); schief@scripps.edu (WRS)

Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: Dr. JJG is an unpaid board member of the Rosetta Commons. Under institutional participation agreements between the University of Washington, acting on behalf of the Rosetta Commons, Johns Hopkins University may be entitled to a portion of revenue received on licensing Rosetta software including methods discussed/developed in this study. As a member of the Scientific Advisory Board, JJG has a financial interest in Cyrus Biotechnology. Cyrus Biotechnology distributes the Rosetta software, which may include methods developed in this study. These arrangements have been reviewed and approved by the Johns Hopkins University in accordance with its conflict-of-interest policies. WRS is an employee of Moderna, Inc., but his contributions to this work were all conducted prior to his employment at Moderna. JAB is an employee of Johnson and Johnson Innovative Medicine, Inc., but his contributions to this work were all conducted prior to his current employment.