Genes for highly abundant proteins in Escherichia coli avoid 5’ codons that promote ribosomal initiation

Loveday E. Lewin; Kate G. Daniels; Laurence D. Hurst

doi:10.1371/journal.pcbi.1011581

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Open Access

Peer-reviewed

Research Article

Genes for highly abundant proteins in Escherichia coli avoid 5’ codons that promote ribosomal initiation

Loveday E. Lewin ,

Contributed equally to this work with: Loveday E. Lewin, Kate G. Daniels

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliation The Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, United Kingdom
⨯
Kate G. Daniels ,

Contributed equally to this work with: Loveday E. Lewin, Kate G. Daniels

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization

Affiliation The Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, United Kingdom
⨯
Laurence D. Hurst

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: l.d.hurst@bath.ac.uk

Affiliation The Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, United Kingdom

https://orcid.org/0000-0002-1002-1054

⨯

Genes for highly abundant proteins in Escherichia coli avoid 5’ codons that promote ribosomal initiation

Loveday E. Lewin,
Kate G. Daniels,
Laurence D. Hurst

Published: October 25, 2023
https://doi.org/10.1371/journal.pcbi.1011581

About the Authors

Loveday E. Lewin

Contributed equally to this work with: Loveday E. Lewin, Kate G. Daniels

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliation The Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, United Kingdom

Kate G. Daniels

Contributed equally to this work with: Loveday E. Lewin, Kate G. Daniels

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization

Affiliation The Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, United Kingdom

Laurence D. Hurst

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: l.d.hurst@bath.ac.uk

Affiliation The Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, United Kingdom

https://orcid.org/0000-0002-1002-1054

Competing Interests

The authors have declared that no competing interests exist.

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Escherichia coli
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Gene expression
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Protein abundance
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Protein translation
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Bacterial genomics
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RNA stability
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Translation initiation
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Transfer RNA
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