Profile-Wise Analysis: A profile likelihood-based workflow for identifiability analysis, estimation, and prediction with mechanistic mathematical models

Matthew J. Simpson; Oliver J. Maclaren

doi:10.1371/journal.pcbi.1011515

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Open Access

Peer-reviewed

Research Article

Profile-Wise Analysis: A profile likelihood-based workflow for identifiability analysis, estimation, and prediction with mechanistic mathematical models

Matthew J. Simpson ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

* E-mail: matthew.simpson@qut.edu.au

Affiliation School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia

https://orcid.org/0000-0001-6254-313X

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Oliver J. Maclaren

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Engineering Science, University of Auckland, Auckland, New Zealand
⨯

Profile-Wise Analysis: A profile likelihood-based workflow for identifiability analysis, estimation, and prediction with mechanistic mathematical models

Matthew J. Simpson,
Oliver J. Maclaren

Published: September 29, 2023
https://doi.org/10.1371/journal.pcbi.1011515

About the Authors

Matthew J. Simpson

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

* E-mail: matthew.simpson@qut.edu.au

Affiliation School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia

https://orcid.org/0000-0001-6254-313X

Oliver J. Maclaren

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Engineering Science, University of Auckland, Auckland, New Zealand

Competing Interests

The authors have declared that no competing interests exist.

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Gaussian noise
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Mathematical models
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Optimization
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Algorithms
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Population density
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Nonlinear systems
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Probability distribution
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