Atomistic simulation of protein evolution reveals sequence covariation and time-dependent fluctuations of site-specific substitution rates

Christoffer Norn; Ingemar André

doi:10.1371/journal.pcbi.1010262

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Open Access

Peer-reviewed

Research Article

Atomistic simulation of protein evolution reveals sequence covariation and time-dependent fluctuations of site-specific substitution rates

Christoffer Norn,

Roles Conceptualization, Methodology, Software, Writing – review & editing

Affiliation Biochemistry and Structural Biology, Lund University, Lund, Sweden
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Ingemar André

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ingemar.andre@biochemistry.lu.se

Affiliation Biochemistry and Structural Biology, Lund University, Lund, Sweden

https://orcid.org/0000-0002-4753-8233

⨯

Atomistic simulation of protein evolution reveals sequence covariation and time-dependent fluctuations of site-specific substitution rates

Christoffer Norn,
Ingemar André

Published: March 24, 2023
https://doi.org/10.1371/journal.pcbi.1010262

About the Authors

Christoffer Norn

Roles Conceptualization, Methodology, Software, Writing – review & editing

Affiliation Biochemistry and Structural Biology, Lund University, Lund, Sweden

Ingemar André

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ingemar.andre@biochemistry.lu.se

Affiliation Biochemistry and Structural Biology, Lund University, Lund, Sweden

https://orcid.org/0000-0002-4753-8233

Competing Interests

The authors have declared that no competing interests exist.

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Biochemical simulations
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Molecular evolution
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Natural selection
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Phylogenetic analysis
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Protein folding
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Substitution mutation
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Evolutionary rate
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Probability distribution
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