Dynamic inference of cell developmental complex energy landscape from time series single-cell transcriptomic data

Qi Jiang; Shuo Zhang; Lin Wan

doi:10.1371/journal.pcbi.1009821

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Open Access

Peer-reviewed

Research Article

Dynamic inference of cell developmental complex energy landscape from time series single-cell transcriptomic data

Qi Jiang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations NCMIS, LSC, LSEC, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, School of Mathematical Sciences, University of Chinese Academy of Sciences, Beijing, China
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Shuo Zhang,

Roles Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – review & editing

Affiliations NCMIS, LSC, LSEC, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, School of Mathematical Sciences, University of Chinese Academy of Sciences, Beijing, China
⨯
Lin Wan

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: lwan@amss.ac.cn

Affiliations NCMIS, LSC, LSEC, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, School of Mathematical Sciences, University of Chinese Academy of Sciences, Beijing, China

https://orcid.org/0000-0002-3511-0512

⨯

Dynamic inference of cell developmental complex energy landscape from time series single-cell transcriptomic data

Qi Jiang,
Shuo Zhang,
Lin Wan

Published: January 24, 2022
https://doi.org/10.1371/journal.pcbi.1009821

About the Authors

Qi Jiang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations NCMIS, LSC, LSEC, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, School of Mathematical Sciences, University of Chinese Academy of Sciences, Beijing, China

Shuo Zhang

Roles Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – review & editing

Lin Wan

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: lwan@amss.ac.cn

https://orcid.org/0000-0002-3511-0512

Competing Interests

The authors have declared that no competing interests exist.

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Potential energy
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Cell differentiation
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Free energy
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Cerebral cortex
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Neurons
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Cell potency
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Nonlinear dynamics
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Probability distribution
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