About the Authors

Vladimir Naumov

Roles Data curation, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Eugene Lane

Roles Investigation, Methodology

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Stefan Pushkov

Roles Data curation, Formal analysis, Validation

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Ekaterina Kozlova

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Konstantin Romantsov

Roles Data curation, Software, Visualization

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Alexander Kalashnikov

Roles Data curation, Resources, Software, Visualization

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Fedor Galkin

Roles Data curation, Investigation, Resources, Software, Visualization

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Nina Tihonova

Roles Data curation, Investigation, Software, Visualization

Affiliations Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong, School of Biology, Lomonosov Moscow State University, Moscow, Russia

Anastasia Shneyderman

Roles Data curation, Methodology, Software, Validation

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Egor Galkin

Roles Data curation, Formal analysis, Software, Validation, Visualization

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Arsenii Zinkevich

Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Stephanie M. Cope

Roles Project administration, Supervision

Affiliation Intel Corporation, Santa Clara, California, United States of America

Ramanathan Sethuraman

Roles Project administration, Supervision

Affiliation Intel Corporation, Bangalore India

Tudor I. Oprea

Roles Conceptualization, Project administration, Supervision

Affiliations Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States of America, Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark

Alexander T. Pearson

Roles Data curation, Formal analysis, Validation

Affiliation Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, Ilinois, United States of America

Savas Tay

Roles Data curation, Resources, Validation

Affiliation Pritzker School of Molecular Engineering, University of Chicago, Chicago, Ilinois, United States of America

Nishant Agrawal

Roles Data curation, Resources, Validation

Affiliation Department of Surgery, Section of Otolaryngology-Head and Neck Surgery, University of Chicago, Chicago, Ilinois, United States of America

Alexey Dubovenko

Roles Project administration

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Quentin Vanhaelen

Roles Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

vanhaelen@insilicomedicine.com

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Ivan Ozerov

Roles Conceptualization, Project administration, Supervision

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Alex Aliper

Roles Conceptualization, Project administration, Supervision

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Evgeny Izumchenko

Roles Formal analysis, Validation, Writing – original draft, Writing – review & editing

‡ These authors are joint senior authors on this work.

Affiliation Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, Ilinois, United States of America

Alex Zhavoronkov

Roles Project administration, Supervision

‡ These authors are joint senior authors on this work.

Affiliation Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: V.N., E.K., Q.V., K.R., A.K., F.G., E.G., A.Z., A.D., I.O., A.A. and A.Z. are affiliated with Insilico Medicine (www.insilico.com), a for-profit company developing critical intellectual property in the field of artificial intelligence for generative biology, chemistry, and prediction of clinical trials outcomes with the aim of complete integration of multiple previously disconnected areas of pharmaceutical drug discovery and development. The company is engaged in aging research to acquire a deep understanding of the longitudinal changes in human biology and the relationship between multiple data types. T.I.O. has received honoraria from or consulted for Abbott, AstraZeneca, Chiron, Genentech, Infinity Pharmaceuticals, Merz Pharmaceuticals, Merck Darmstadt, Mitsubishi Tanabe, Novartis, Ono Pharmaceuticals, Pfizer, Roche, Sanofi, Wyeth and Insilico Medicine. All other authors declare no conflict of interest.