Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data

Nima Nouri; Steven H. Kleinstein

doi:10.1371/journal.pcbi.1007977

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Open Access

Peer-reviewed

Research Article

Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data

Nima Nouri,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Pathology, Yale School of Medicine, New Haven, Connecticut, United States of America, Center for Medical Informatics, Yale School of Medicine, New Haven, Connecticut, United States of America

http://orcid.org/0000-0001-8348-5717

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Steven H. Kleinstein

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: steven.kleinstein@yale.edu

Affiliations Department of Pathology, Yale School of Medicine, New Haven, Connecticut, United States of America, Center for Medical Informatics, Yale School of Medicine, New Haven, Connecticut, United States of America, Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

http://orcid.org/0000-0003-4957-1544

⨯

Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data

Nima Nouri,
Steven H. Kleinstein

Published: June 23, 2020
https://doi.org/10.1371/journal.pcbi.1007977

About the Authors

Nima Nouri

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

http://orcid.org/0000-0001-8348-5717

Steven H. Kleinstein

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: steven.kleinstein@yale.edu

Affiliations Department of Pathology, Yale School of Medicine, New Haven, Connecticut, United States of America, Center for Medical Informatics, Yale School of Medicine, New Haven, Connecticut, United States of America, Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

http://orcid.org/0000-0003-4957-1544

Competing Interests

I have read the journal’s policy and the one of the authors of this manuscript have the following competing interests: S.H.K. receives consulting fees from Northrop Grumman.

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Cloning
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B cells
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Recombination-based assay
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Spectral clustering
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Nucleotide sequencing
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Algorithms
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Nucleotides
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Substitution mutation
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