Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference

• Chunhui Cai,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

  http://orcid.org/0000-0002-1742-4999

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• Gregory F. Cooper,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

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• Kevin N. Lu,

  Roles Data curation, Formal analysis, Software

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

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• Xiaojun Ma,

  Roles Data curation, Software

  Affiliation Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Shuping Xu,

  Roles Validation

  Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Zhenlong Zhao,

  Roles Validation

  Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Xueer Chen,

  Roles Data curation, Formal analysis, Software

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

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• Yifan Xue,

  Roles Data curation, Formal analysis

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

  http://orcid.org/0000-0003-4068-2707

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• Adrian V. Lee,

  Roles Conceptualization, Investigation

  Affiliations Center for Causal Discovery, Pittsburgh, PA, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America, Magee Women’s Cancer Research Center, Pittsburgh, PA, United States of America, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America

  http://orcid.org/0000-0001-9917-514X

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• Nathan Clark,

  Roles Investigation

  Affiliations Center for Causal Discovery, Pittsburgh, PA, United States of America, Department of Computational Biology and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Vicky Chen,

  Roles Data curation, Formal analysis

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

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• Songjian Lu,

  Roles Investigation, Methodology

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

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• Lujia Chen,

  Roles Data curation, Formal analysis

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

  http://orcid.org/0000-0003-4157-0440

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• Liyue Yu,

  Roles Data curation, Formal analysis, Software

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

  http://orcid.org/0000-0001-8967-7920

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• Harry S. Hochheiser,

  Roles Data curation

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

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• Xia Jiang,

  Roles Methodology

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America

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• Q. Jane Wang ,

  Roles Formal analysis, Investigation, Validation, Visualization, Writing – original draft

  * E-mail: qjw1@pitt.edu (QJW); xinghua@pitt.edu (XL)

  Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America

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•  [ ... ],
• Xinghua Lu

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: qjw1@pitt.edu (QJW); xinghua@pitt.edu (XL)

  Affiliations Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Causal Discovery, Pittsburgh, PA, United States of America, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America

  http://orcid.org/0000-0002-8599-2269

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