About the Authors

Marzieh Ayati

Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliations Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, Department of Computer Science, University of Texas Rio Grande Valley, Edinburg, TX

Danica Wiredja

Roles Data curation, Formal analysis

Affiliation Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH

Daniela Schlatzer

Roles Data curation, Formal analysis

Affiliation Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH

Sean Maxwell

Roles Data curation, Formal analysis

Affiliation Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH

Ming Li

Roles Supervision

Affiliations Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH

Mehmet Koyutürk

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH

Mark R. Chance

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

mark.chance@case.edu

Affiliations Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, Department of Nutrition, Case Western Reserve University, Cleveland, OH

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: The patent application is pending from Case Western Reserve University. The patent is about the methodology to identify enzyme-substrate association using co-substrate analysis.