General principles of binding between cell surface receptors and multi-specific ligands: A computational study

Jiawen Chen; Steven C. Almo; Yinghao Wu

doi:10.1371/journal.pcbi.1005805

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Open Access

Peer-reviewed

Research Article

General principles of binding between cell surface receptors and multi-specific ligands: A computational study

Jiawen Chen,

Roles Data curation, Formal analysis

Affiliation Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Steven C. Almo,

Roles Writing – review & editing

Affiliations Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Yinghao Wu

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft

* E-mail: yinghao.wu@einstein.yu.edu

Affiliation Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

http://orcid.org/0000-0003-1181-5670

⨯

General principles of binding between cell surface receptors and multi-specific ligands: A computational study

Jiawen Chen,
Steven C. Almo,
Yinghao Wu

Published: October 10, 2017
https://doi.org/10.1371/journal.pcbi.1005805

About the Authors

Jiawen Chen

Roles Data curation, Formal analysis

Affiliation Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Steven C. Almo

Roles Writing – review & editing

Affiliations Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York, United States of America

Yinghao Wu

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft

* E-mail: yinghao.wu@einstein.yu.edu

Affiliation Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

http://orcid.org/0000-0003-1181-5670

Competing Interests

The authors have declared that no competing interests exist.

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Cell binding
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Membrane receptor signaling
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Cell membranes
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Drug interactions
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Monomers
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Simulation and modeling
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Biomacromolecule-ligand interactions
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Receptor-ligand binding assay
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