Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies

Open Access

Peer-reviewed

Research Article

About the Authors

Burcu Tepekule

Roles Writing – original draft, Writing – review & editing

Affiliation Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland

Hildegard Uecker

Roles Writing – review & editing

Affiliation Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland

Isabel Derungs

Roles Writing – review & editing

Affiliation Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland

Antoine Frenoy

Roles Writing – review & editing

Affiliation Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland

Sebastian Bonhoeffer

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland

The authors have declared that no competing interests exist.

Drug therapy
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Linear discriminant analysis
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Antibiotic resistance
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Superinfection
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Optimization
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Antibiotics
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Evolutionary emergence
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Mathematical models
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