Host population structure impedes reversion to drug sensitivity after discontinuation of treatment

Jonas I. Liechti; Gabriel E. Leventhal; Sebastian Bonhoeffer

doi:10.1371/journal.pcbi.1005704

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Open Access

Peer-reviewed

Research Article

Host population structure impedes reversion to drug sensitivity after discontinuation of treatment

Jonas I. Liechti ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: jonas.liechti@env.ethz.ch

Affiliation Institute for Integrative Biology, ETH Zürich, Zürich, Switzerland

http://orcid.org/0000-0003-3447-3060

⨯
Gabriel E. Leventhal,

Roles Conceptualization, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Institute for Integrative Biology, ETH Zürich, Zürich, Switzerland, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

http://orcid.org/0000-0002-4463-166X

⨯
Sebastian Bonhoeffer

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Institute for Integrative Biology, ETH Zürich, Zürich, Switzerland

http://orcid.org/0000-0001-8052-3925

⨯

Host population structure impedes reversion to drug sensitivity after discontinuation of treatment

Jonas I. Liechti,
Gabriel E. Leventhal,
Sebastian Bonhoeffer

Published: August 21, 2017
https://doi.org/10.1371/journal.pcbi.1005704

About the Authors

Jonas I. Liechti

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: jonas.liechti@env.ethz.ch

Affiliation Institute for Integrative Biology, ETH Zürich, Zürich, Switzerland

http://orcid.org/0000-0003-3447-3060

Gabriel E. Leventhal

Roles Conceptualization, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Institute for Integrative Biology, ETH Zürich, Zürich, Switzerland, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

http://orcid.org/0000-0002-4463-166X

Sebastian Bonhoeffer

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Institute for Integrative Biology, ETH Zürich, Zürich, Switzerland

http://orcid.org/0000-0001-8052-3925

Competing Interests

The authors have declared that no competing interests exist.

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Pathogens
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Evolutionary emergence
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Antibiotic resistance
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Probability distribution
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Drug therapy
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Probability density
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Evolutionary immunology
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Population dynamics
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