About the Authors

Yang Li

Roles Conceptualization, Formal analysis, Methodology, Software, Writing – original draft

Affiliations Howard Hughes Medical Institute and Department of Molecular Biology and the Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America and Department of Systems Biology, Harvard Medical School, Boston, MA United States of America, Department of Statistics, Harvard University, Cambridge, MA, United States of America

Alexis A. Jourdain

Roles Investigation, Validation

Affiliations Howard Hughes Medical Institute and Department of Molecular Biology and the Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America and Department of Systems Biology, Harvard Medical School, Boston, MA United States of America, Broad Institute, Cambridge, MA, United States of America

Sarah E. Calvo

Roles Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

scalvo@broadinstitute.org (SEC); jliu@stat.harvard.edu (JSL); vamsi@hms.harvard.edu(VKM)

Affiliations Howard Hughes Medical Institute and Department of Molecular Biology and the Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America and Department of Systems Biology, Harvard Medical School, Boston, MA United States of America, Broad Institute, Cambridge, MA, United States of America

Jun S. Liu

Roles Conceptualization, Supervision, Writing – review & editing

scalvo@broadinstitute.org (SEC); jliu@stat.harvard.edu (JSL); vamsi@hms.harvard.edu(VKM)

Affiliation Department of Statistics, Harvard University, Cambridge, MA, United States of America

Vamsi K. Mootha

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

scalvo@broadinstitute.org (SEC); jliu@stat.harvard.edu (JSL); vamsi@hms.harvard.edu(VKM)

Affiliations Howard Hughes Medical Institute and Department of Molecular Biology and the Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America and Department of Systems Biology, Harvard Medical School, Boston, MA United States of America, Broad Institute, Cambridge, MA, United States of America

Competing Interests

The authors have declared that no competing interests exist.