Inherent limitations of probabilistic models for protein-DNA binding specificity

Shuxiang Ruan; Gary D. Stormo

doi:10.1371/journal.pcbi.1005638

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Open Access

Peer-reviewed

Research Article

Inherent limitations of probabilistic models for protein-DNA binding specificity

Shuxiang Ruan,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Genetics and The Edison Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Gary D. Stormo

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: stormo@wustl.edu

Affiliation Department of Genetics and The Edison Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

http://orcid.org/0000-0001-6896-1850

⨯

Inherent limitations of probabilistic models for protein-DNA binding specificity

Shuxiang Ruan,
Gary D. Stormo

Published: July 7, 2017
https://doi.org/10.1371/journal.pcbi.1005638

About the Authors

Shuxiang Ruan

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Genetics and The Edison Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Gary D. Stormo

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: stormo@wustl.edu

Affiliation Department of Genetics and The Edison Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

http://orcid.org/0000-0001-6896-1850

Competing Interests

The authors declare that no competing interests exist.

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Biophysics
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DNA-binding proteins
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Protein interactions
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Algorithms
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Biochemical simulations
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Approximation methods
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Probability distribution
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Transcription factors
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