NetNorM: Capturing cancer-relevant information in somatic exome mutation data with gene networks for cancer stratification and prognosis

Marine Le Morvan; Andrei Zinovyev; Jean-Philippe Vert

doi:10.1371/journal.pcbi.1005573

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Open Access

Peer-reviewed

Research Article

NetNorM: Capturing cancer-relevant information in somatic exome mutation data with gene networks for cancer stratification and prognosis

Marine Le Morvan,

Affiliations MINES ParisTech, PSL Research University, CBIO-Centre for Computational Biology, 75006 Paris, France, Institut Curie, 75248 Paris Cedex 5, France, INSERM, U900, 75248 Paris Cedex 5, France

http://orcid.org/0000-0001-9899-221X

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Andrei Zinovyev,

Affiliations MINES ParisTech, PSL Research University, CBIO-Centre for Computational Biology, 75006 Paris, France, Institut Curie, 75248 Paris Cedex 5, France, INSERM, U900, 75248 Paris Cedex 5, France

http://orcid.org/0000-0002-9517-7284

⨯
Jean-Philippe Vert

* E-mail: jean-philippe.vert@mines-paristech.fr

Affiliations MINES ParisTech, PSL Research University, CBIO-Centre for Computational Biology, 75006 Paris, France, Institut Curie, 75248 Paris Cedex 5, France, INSERM, U900, 75248 Paris Cedex 5, France, Department of Mathematics and Applications, Ecole normale supérieure, CNRS, PSL Research University, 75005 Paris, France

http://orcid.org/0000-0001-9510-8441

⨯

NetNorM: Capturing cancer-relevant information in somatic exome mutation data with gene networks for cancer stratification and prognosis

Marine Le Morvan,
Andrei Zinovyev,
Jean-Philippe Vert

Published: June 26, 2017
https://doi.org/10.1371/journal.pcbi.1005573

About the Authors

Marine Le Morvan

http://orcid.org/0000-0001-9899-221X

Andrei Zinovyev

http://orcid.org/0000-0002-9517-7284

Jean-Philippe Vert

* E-mail: jean-philippe.vert@mines-paristech.fr

Affiliations MINES ParisTech, PSL Research University, CBIO-Centre for Computational Biology, 75006 Paris, France, Institut Curie, 75248 Paris Cedex 5, France, INSERM, U900, 75248 Paris Cedex 5, France, Department of Mathematics and Applications, Ecole normale supérieure, CNRS, PSL Research University, 75005 Paris, France

http://orcid.org/0000-0001-9510-8441

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: MLV AZ JPV. Data curation: MLV. Formal analysis: MLV. Funding acquisition: JPV. Investigation: MLV. Methodology: MLV AZ JPV. Project administration: JPV. Resources: AZ JPV. Software: MLV. Supervision: AZ JPV. Validation: MLV JPV. Visualization: MLV. Writing – original draft: MLV JPV. Writing – review & editing: MLV AZ JPV.

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Mutation
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Cancers and neoplasms
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Somatic mutation
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Point mutation
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Gene regulatory networks
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Breast cancer
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Genetic networks
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Malignant tumors
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