About the Authors

Julia Chifman

Contributed equally to this work with: Julia Chifman, Seda Arat

Affiliation Department of Mathematics and Statistics, American University, Washington, DC, USA

Seda Arat

Contributed equally to this work with: Julia Chifman, Seda Arat

Affiliation The Jackson Laboratory, Bar Harbor, ME, USA

Zhiyong Deng

Affiliation Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT, USA

Erica Lemler

Affiliation Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT, USA

James C. Pino

Affiliation Chemical and Physical Biology Graduate Program, Vanderbilt University, Nashville, TN, USA

Leonard A. Harris

Affiliation Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA

Michael A. Kochen

Affiliation Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA

Carlos F. Lopez

Affiliations Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA, Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA, Center for Quantitative Science, Vanderbilt University, Nashville, TN, USA

Steven A. Akman

Affiliation Cancer Program, Roper St Francis HealthCare, Charleston, SC, USA

Frank M. Torti

Affiliation Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA

Suzy V. Torti

Affiliation Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT, USA

Reinhard Laubenbacher

laubenbacher@uchc.edu

Affiliations Center for Quantitative Medicine, University of Connecticut Health Center, Farmington, CT, USA, The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZD EL. Performed the experiments: ZD EL. Analyzed the data: JC SA. Contributed reagents/materials/analysis tools: SVT FMT SAA RL. Wrote the paper: JC SA RL. Developed the concept of the project: JC RL. Led network construction, mathematical model development and attractor analysis: JC SA. Designed and wrote the codes for model simulations and attractor analysis: JC SA JCP LAH MAK CFL. Directed the project: RL.