Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communication

Gabrielle Stetz; Gennady M. Verkhivker

doi:10.1371/journal.pcbi.1005299

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Open Access

Peer-reviewed

Research Article

Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communication

Gabrielle Stetz,

Affiliation Graduate Program in Computational and Data Sciences, Schmid College of Science and Technology, Chapman University, Orange, California, United States of America
⨯
Gennady M. Verkhivker

* E-mail: verkhivk@chapman.edu

Affiliations Graduate Program in Computational and Data Sciences, Schmid College of Science and Technology, Chapman University, Orange, California, United States of America, Chapman University School of Pharmacy, Irvine, California, United States of America
⨯

Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communication

Gabrielle Stetz,
Gennady M. Verkhivker

Published: January 17, 2017
https://doi.org/10.1371/journal.pcbi.1005299

About the Authors

Gabrielle Stetz

Affiliation Graduate Program in Computational and Data Sciences, Schmid College of Science and Technology, Chapman University, Orange, California, United States of America

Gennady M. Verkhivker

* E-mail: verkhivk@chapman.edu

Affiliations Graduate Program in Computational and Data Sciences, Schmid College of Science and Technology, Chapman University, Orange, California, United States of America, Chapman University School of Pharmacy, Irvine, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: GMV. Data curation: GS GMV. Formal analysis: GS GMV. Funding acquisition: GMV. Investigation: GS GMV. Methodology: GMV. Project administration: GMV. Resources: GMV. Software: GS GMV. Supervision: GMV. Validation: GMV. Visualization: GMV. Writing – original draft: GMV. Writing – review & editing: GMV.

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Allosteric regulation
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Crystal structure
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DNA structure
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Centrality
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Interaction networks
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Protein interaction networks
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Protein structure
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Nucleotides
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