Functionality and Robustness of Injured Connectomic Dynamics in C. elegans: Linking Behavioral Deficits to Neural Circuit Damage

James M. Kunert; Pedro D. Maia; J. Nathan Kutz

doi:10.1371/journal.pcbi.1005261

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Open Access

Peer-reviewed

Research Article

Functionality and Robustness of Injured Connectomic Dynamics in C. elegans: Linking Behavioral Deficits to Neural Circuit Damage

James M. Kunert ,

* E-mail: kunert@uw.edu (JMK); pmaia@uw.edu (PDM); kutz@uw.edu (JNK)

Affiliation Department of Physics, University of Washington, Seattle, Washington, United States of America
⨯
Pedro D. Maia ,

* E-mail: kunert@uw.edu (JMK); pmaia@uw.edu (PDM); kutz@uw.edu (JNK)

Affiliation Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America
⨯
J. Nathan Kutz

* E-mail: kunert@uw.edu (JMK); pmaia@uw.edu (PDM); kutz@uw.edu (JNK)

Affiliation Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America
⨯

Functionality and Robustness of Injured Connectomic Dynamics in C. elegans: Linking Behavioral Deficits to Neural Circuit Damage

James M. Kunert,
Pedro D. Maia,
J. Nathan Kutz

Published: January 5, 2017
https://doi.org/10.1371/journal.pcbi.1005261

About the Authors

James M. Kunert

* E-mail: kunert@uw.edu (JMK); pmaia@uw.edu (PDM); kutz@uw.edu (JNK)

Affiliation Department of Physics, University of Washington, Seattle, Washington, United States of America

Pedro D. Maia

* E-mail: kunert@uw.edu (JMK); pmaia@uw.edu (PDM); kutz@uw.edu (JNK)

Affiliation Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America

J. Nathan Kutz

* E-mail: kunert@uw.edu (JMK); pmaia@uw.edu (PDM); kutz@uw.edu (JNK)

Affiliation Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: JMK PDM JNK. Data curation: JMK. Formal analysis: JMK. Funding acquisition: JNK. Investigation: JMK PDM JNK. Methodology: JMK PDM JNK. Project administration: JMK PDM JNK. Resources: JMK PDM JNK. Software: JMK. Supervision: PDM JNK. Validation: JMK PDM JNK. Visualization: JMK PDM JNK. Writing – original draft: JMK PDM JNK. Writing – review & editing: JMK PDM JNK.

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Neurons
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Behavior
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Neural networks
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Animal behavior
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Traumatic brain injury
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Caenorhabditis elegans
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Crawling
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Connectomics
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