About the Authors

Andrew K. Smith

Affiliation Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States of America

Brenden K. Petersen

Affiliation UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, Berkeley, CA, United States of America

Glen E. P. Ropella

Affiliation Tempus Dictum, Inc., Milwaukie, OR, United States of America

Ryan C. Kennedy

Affiliation Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States of America

Neil Kaplowitz

Affiliation Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America

Murad Ookhtens

Affiliation Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America

C. Anthony Hunt

a.hunt@ucsf.edu

Affiliation Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CAH AKS GEPR. Performed the experiments: AKS GEPR. Analyzed the data: AKS BKP GEPR RCK NK MO CAH. Wrote the paper: AKS CAH BKP GEPR RCK. Developed and verified Mouse Analog and sub-component requirements: AKS BKP GEPR. Guided refinements of analog to mouse mappings: AKS NK MO CAH. Contributed to TA selection and SC development: NK MO CAH. Helped complete IR Protocol cycles: BKP GEPR RCK. Designed and executed batch sampling: AKS GEPR. Managed and executed cloud experiments: AKS GEPR. Managed current versioning: GEPR. Conducted unit tests: BKP GER. Contributed Mouse Analog components: BKP. Developed scripts for data analyses and data visualizations: AKS GEPR. Conducted component/module validation experiments: BKP GEPR. Provided quantitative expert opinions: NK MO. Contributed manuscript content: AKS BKP GEPR RCK CAH. Guided the research: NK CAH.