Inferring Aggregated Functional Traits from Metagenomic Data Using Constrained Non-negative Matrix Factorization: Application to Fiber Degradation in the Human Gut Microbiota

Sébastien Raguideau; Sandra Plancade; Nicolas Pons; Marion Leclerc; Béatrice Laroche

doi:10.1371/journal.pcbi.1005252

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Open Access

Peer-reviewed

Research Article

Inferring Aggregated Functional Traits from Metagenomic Data Using Constrained Non-negative Matrix Factorization: Application to Fiber Degradation in the Human Gut Microbiota

Sébastien Raguideau,

Affiliations Institut Micalis, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France, MaIAGE, INRA, Université Paris-Saclay, Jouy-en-Josas, France
⨯
Sandra Plancade,

Affiliation MaIAGE, INRA, Université Paris-Saclay, Jouy-en-Josas, France
⨯
Nicolas Pons,

Affiliation MGP, INRA, Université Paris-Saclay, Jouy-en-Josas, France
⨯
Marion Leclerc,

Affiliation Institut Micalis, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France
⨯
Béatrice Laroche

* E-mail: Beatrice.Laroche@inra.fr

Affiliation MaIAGE, INRA, Université Paris-Saclay, Jouy-en-Josas, France

http://orcid.org/0000-0001-7821-332X

⨯

Inferring Aggregated Functional Traits from Metagenomic Data Using Constrained Non-negative Matrix Factorization: Application to Fiber Degradation in the Human Gut Microbiota

Sébastien Raguideau,
Sandra Plancade,
Nicolas Pons,
Marion Leclerc,
Béatrice Laroche

Published: December 16, 2016
https://doi.org/10.1371/journal.pcbi.1005252

About the Authors

Sébastien Raguideau

Affiliations Institut Micalis, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France, MaIAGE, INRA, Université Paris-Saclay, Jouy-en-Josas, France

Sandra Plancade

Affiliation MaIAGE, INRA, Université Paris-Saclay, Jouy-en-Josas, France

Nicolas Pons

Affiliation MGP, INRA, Université Paris-Saclay, Jouy-en-Josas, France

Marion Leclerc

Affiliation Institut Micalis, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France

Béatrice Laroche

* E-mail: Beatrice.Laroche@inra.fr

Affiliation MaIAGE, INRA, Université Paris-Saclay, Jouy-en-Josas, France

http://orcid.org/0000-0001-7821-332X

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: SR SP ML BL. Data curation: NP SR. Formal analysis: SR SP BL. Software: SR. Validation: SR ML. Writing – original draft: SR SP ML BL.

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Metabolites
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Microbial ecosystems
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Metabolic processes
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Genomics
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Ecosystem functioning
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Ecosystems
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Metagenomics
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Fermentation
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