Sparse Regression Based Structure Learning of Stochastic Reaction Networks from Single Cell Snapshot Time Series

Anna Klimovskaia; Stefan Ganscha; Manfred Claassen

doi:10.1371/journal.pcbi.1005234

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Open Access

Peer-reviewed

Research Article

Sparse Regression Based Structure Learning of Stochastic Reaction Networks from Single Cell Snapshot Time Series

Anna Klimovskaia,

Affiliations Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Zurich, Switzerland, Life Science Zurich Graduate School, Zurich, Switzerland

http://orcid.org/0000-0002-1057-6690

⨯
Stefan Ganscha,

Affiliations Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Zurich, Switzerland, Life Science Zurich Graduate School, Zurich, Switzerland
⨯
Manfred Claassen

* E-mail: claassen@imsb.biol.ethz.ch

Affiliations Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Zurich, Switzerland
⨯

Sparse Regression Based Structure Learning of Stochastic Reaction Networks from Single Cell Snapshot Time Series

Anna Klimovskaia,
Stefan Ganscha,
Manfred Claassen

Published: December 6, 2016
https://doi.org/10.1371/journal.pcbi.1005234

About the Authors

Anna Klimovskaia

Affiliations Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Zurich, Switzerland, Life Science Zurich Graduate School, Zurich, Switzerland

http://orcid.org/0000-0002-1057-6690

Stefan Ganscha

Affiliations Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Zurich, Switzerland, Life Science Zurich Graduate School, Zurich, Switzerland

Manfred Claassen

* E-mail: claassen@imsb.biol.ethz.ch

Affiliations Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Zurich, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: AK SG MC. Formal analysis: AK MC. Funding acquisition: MC. Investigation: AK. Methodology: AK MC. Project administration: MC. Software: AK. Supervision: MC. Validation: AK. Visualization: AK MC. Writing – original draft: AK MC. Writing – review & editing: AK SG MC.

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Apoptosis
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Chemical reactions
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RNA structure
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Learning
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Stoichiometry
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Differential equations
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Network analysis
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Signaling cascades
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