About the Authors

Peter Rashkov

Affiliation School of Biosciences, University of Exeter, Exeter, United Kingdom

Ian P. Barrett

Affiliation Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom

Robert E. Beardmore

Affiliation School of Biosciences, University of Exeter, Exeter, United Kingdom

Claus Bendtsen

Claus.Bendtsen@astrazeneca.com (CB); I.Gudelj@exeter.ac.uk (IG)

Affiliation Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom

Ivana Gudelj

Claus.Bendtsen@astrazeneca.com (CB); I.Gudelj@exeter.ac.uk (IG)

Affiliation School of Biosciences, University of Exeter, Exeter, United Kingdom

Competing Interests

IPB and CB were employees of AstraZeneca at time of writing of the manuscript. This does not alter the authors’ adherence to PLOS policies on sharing data and materials.

Author Contributions

Conceptualization: IG CB IPB REB. Formal analysis: PR. Funding acquisition: IG REB. Methodology: PR IG IPB CB. Software: PR. Supervision: IG REB IPB CB. Writing – original draft: IG REB IPB CB PR.