About the Authors

K. Aurelia Ball

Affiliation Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California, United States of America

Jeffrey R. Johnson

Affiliation Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California, United States of America

Mary K. Lewinski

Affiliation Division of Infectious Diseases, University of California at San Diego School of Medicine, La Jolla, California, United States of America

John Guatelli

Affiliation Division of Infectious Diseases, University of California at San Diego School of Medicine, La Jolla, California, United States of America

Erik Verschueren

Affiliation Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California, United States of America

Nevan J. Krogan

nevan.krogan@ucsf.edu (NJK); matt.jacobson@ucsf.edu (MPJ)

Affiliation Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California, United States of America

Matthew P. Jacobson

nevan.krogan@ucsf.edu (NJK); matt.jacobson@ucsf.edu (MPJ)

Affiliation Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California, United States of America

Competing Interests

MPJ is a consultant to Schrodinger LLC, which licenses some of the software used in this work.

Author Contributions

Conceived and designed the experiments: KAB JRJ JG NJK MPJ. Performed the experiments: KAB JRJ MKL JG. Analyzed the data: KAB JRJ MKL JG EV. Contributed reagents/materials/analysis tools: JRJ MKL JG EV. Wrote the paper: KAB JRJ EV MPJ.