About the Authors

John D. O’Brien

jobrien@bowdoin.edu

Affiliation Mathematics Department, Bowdoin College, Brunswick, Maine, United States of America

Zamin Iqbal

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom

Jason Wendler

Affiliation Pacific Northwest National Laboratory, Richland, Washington, United States of America

Lucas Amenga-Etego

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom, Navrongo Health Research Centre, Navrongo, Upper East Region, Ghana

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Wrote the paper: JDO ZI LAE JW. Designed and implemented the study: JDO. Commented on the study design: ZI LAE. Generated artificial mixture data: JW. Performed all computational experiments: JDO. Performed data analysis: JDO. Commented on the analysis: ZI. Contributed all of the clinical data: LAE. Wrote and implemented the analysis tools: JDO. Commented on the development of the analysis tools: ZI.