Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case

Farshid S. Garmaroudi; Diane E. Handy; Yang-Yu Liu; Joseph Loscalzo

doi:10.1371/journal.pcbi.1004822

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Peer-reviewed

Research Article

Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case

Farshid S. Garmaroudi,

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Diane E. Handy,

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yang-Yu Liu,

Affiliation Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Joseph Loscalzo

* E-mail: jloscalzo@partners.org

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case

Farshid S. Garmaroudi,
Diane E. Handy,
Yang-Yu Liu,
Joseph Loscalzo

Published: March 17, 2016
https://doi.org/10.1371/journal.pcbi.1004822

About the Authors

Farshid S. Garmaroudi

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Diane E. Handy

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Yang-Yu Liu

Affiliation Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Joseph Loscalzo

* E-mail: jloscalzo@partners.org

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FSG JL YYL. Performed the experiments: FSG YYL DEH. Analyzed the data: FSG JL YYL DEH. Contributed reagents/materials/analysis tools: JL YYL. Wrote the paper: FSG DEH YYL JL.

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cGMP signaling
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Oxidative stress
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Body limbs
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Hydrogen peroxide
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Oxidation
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Pulmonary arteries
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Toxicity
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Cardiovascular therapy
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