Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications

Vaclav Cvicek; William A. Goddard III; Ravinder Abrol

doi:10.1371/journal.pcbi.1004805

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Open Access

Peer-reviewed

Research Article

Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications

Vaclav Cvicek,

Affiliations Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, United States of America
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William A. Goddard III ,

* E-mail: abrolr@csmc.edu (RA); wag@wag.caltech.edu (WAG)

Affiliation Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America
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Ravinder Abrol

* E-mail: abrolr@csmc.edu (RA); wag@wag.caltech.edu (WAG)

Affiliations Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America, Departments of Biomedical Sciences and Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
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Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications

Vaclav Cvicek,
William A. Goddard III,
Ravinder Abrol

Published: March 30, 2016
https://doi.org/10.1371/journal.pcbi.1004805

About the Authors

Vaclav Cvicek

Affiliations Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, United States of America

William A. Goddard III

* E-mail: abrolr@csmc.edu (RA); wag@wag.caltech.edu (WAG)

Affiliation Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America

Ravinder Abrol

* E-mail: abrolr@csmc.edu (RA); wag@wag.caltech.edu (WAG)

Affiliations Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America, Departments of Biomedical Sciences and Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RA VC WAG. Performed the experiments: VC. Analyzed the data: VC WAG RA. Wrote the paper: VC WAG RA.

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G protein coupled receptors
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Sequence alignment
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Crystal structure
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Protein structure comparison
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Multiple alignment calculation
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Phylogenetic analysis
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Protein structure prediction
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Mutation databases
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