About the Authors

Piotr J. Kamola

Affiliations Department of Surgery and Cancer, Imperial College London, London, United Kingdom, Safety Assessment, GlaxoSmithKline R&D, Ware, Hertfordshire, United Kingdom, Computational Biology, GlaxoSmithKline R&D, Stevenage, Hertfordshire, United Kingdom, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Harwell Science and Innovation Campus, United Kingdom

Yuko Nakano

Affiliation Department of Biological Sciences, University of Tokyo, Bunkyo, Tokyo, Japan

Tomoko Takahashi

Affiliation Department of Biological Sciences, University of Tokyo, Bunkyo, Tokyo, Japan

Paul A. Wilson

Affiliation Computational Biology, GlaxoSmithKline R&D, Stevenage, Hertfordshire, United Kingdom

Kumiko Ui-Tei

ktei@bs.s.u-tokyo.ac.jp

Affiliations Department of Biological Sciences, University of Tokyo, Bunkyo, Tokyo, Japan, Department of Computational Biology and Medical Sciences, University of Tokyo, Kashiwa, Chiba, Japan

Competing Interests

PAW is a paid employee of GlaxoSmithKline (GSK) and PJK's EPSRC Industrial CASE doctoral studentships is co-sponsored by GSK. This does not alter our adherence to the PLOS policies on sharing data and materials. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PJK KUT. Performed the experiments: YN TT. Analyzed the data: PJK. Contributed reagents/materials/analysis tools: PJK KUT. Wrote the paper: PJK PAW KUT.