SAAS-CNV: A Joint Segmentation Approach on Aggregated and Allele Specific Signals for the Identification of Somatic Copy Number Alterations with Next-Generation Sequencing Data

Zhongyang Zhang; Ke Hao

doi:10.1371/journal.pcbi.1004618

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Peer-reviewed

Research Article

SAAS-CNV: A Joint Segmentation Approach on Aggregated and Allele Specific Signals for the Identification of Somatic Copy Number Alterations with Next-Generation Sequencing Data

Zhongyang Zhang ,

* E-mail: zhongyang.zhang@mssm.edu (ZZ); ke.hao@mssm.edu (KH)

Affiliations Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Ke Hao

* E-mail: zhongyang.zhang@mssm.edu (ZZ); ke.hao@mssm.edu (KH)

Affiliations Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Respiratory Medicine, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China
⨯

SAAS-CNV: A Joint Segmentation Approach on Aggregated and Allele Specific Signals for the Identification of Somatic Copy Number Alterations with Next-Generation Sequencing Data

Zhongyang Zhang,
Ke Hao

Published: November 19, 2015
https://doi.org/10.1371/journal.pcbi.1004618

About the Authors

Zhongyang Zhang

* E-mail: zhongyang.zhang@mssm.edu (ZZ); ke.hao@mssm.edu (KH)

Affiliations Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Ke Hao

* E-mail: zhongyang.zhang@mssm.edu (ZZ); ke.hao@mssm.edu (KH)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZZ KH. Performed the experiments: ZZ. Analyzed the data: ZZ. Contributed reagents/materials/analysis tools: ZZ KH. Wrote the paper: ZZ KH.

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Cancers and neoplasms
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Single nucleotide polymorphisms
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Malignant tumors
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Genomic signal processing
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Cancer genomics
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Heterozygosity
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Genomics
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Hepatocellular carcinoma
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