About the Authors

David Bednar

Contributed equally to this work with: David Bednar, Koen Beerens

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic

Koen Beerens

Contributed equally to this work with: David Bednar, Koen Beerens

Affiliation Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic

Eva Sebestova

Affiliation Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic

Jaroslav Bendl

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic, Department of Information Systems, Faculty of Information Technology, Brno University of Technology, Brno, Czech Republic

Sagar Khare

Affiliation Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America

Radka Chaloupkova

Affiliation Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic

Zbynek Prokop

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic, Enantis, Ltd., Brno, Czech Republic

Jan Brezovsky

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic

David Baker

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Jiri Damborsky

jiri@chemi.muni.cz

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic, Enantis, Ltd., Brno, Czech Republic

Competing Interests

JD and ZP are founders of the university spin-off company Enantis Ltd. All other authors have no competing interests.

Author Contributions

Conceived and designed the experiments: DBe KB ES JBe RC ZP JBr SK DBa JD. Performed the experiments: DBe KB ES JBe RC JBr. Analyzed the data: DBe KB ES JBe SK RC ZP JBr DBa JD. Wrote the paper: DBe KB ZP JBr JD.