About the Authors

Juan A. Delgado-SanMartin

juan.ads.delgado@astrazeneca.com

‡ JADSM and JWTY contributed equally to this work. JWTY is a senior author. JIH and APSM also contributed equally to this work. APSM is a senior author.

Affiliations Modelling & Simulation Oncology DMPK, AstraZeneca, Cambridge, United Kingdom, Physics Department, University of Aberdeen, Aberdeen, United Kingdom

Jennifer I. Hare

‡ JADSM and JWTY contributed equally to this work. JWTY is a senior author. JIH and APSM also contributed equally to this work. APSM is a senior author.

Affiliation In vivo bioscience, AstraZeneca, Macclesfield, United Kingdom

Alessandro P. S. de Moura

‡ JADSM and JWTY contributed equally to this work. JWTY is a senior author. JIH and APSM also contributed equally to this work. APSM is a senior author.

Affiliation Physics Department, University of Aberdeen, Aberdeen, United Kingdom

James W. T. Yates

‡ JADSM and JWTY contributed equally to this work. JWTY is a senior author. JIH and APSM also contributed equally to this work. APSM is a senior author.

Affiliation Modelling & Simulation Oncology DMPK, AstraZeneca, Cambridge, United Kingdom

Competing Interests

JIH and JWTY are paid employees of AstraZeneca. This does not alter the authors adherence to PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JADSM APSM JWTY. Performed the experiments: JIH. Analyzed the data: JADSM. Contributed reagents/materials/analysis tools: JADSM JIH. Wrote the paper: JADSM JIH JWTY APSM.