About the Authors

Tri Hieu Nim

Affiliations Computational Systems Biology Programme, Singapore-MIT Alliance, Singapore, Systems Biology Institute (SBI), Clayton, Victoria, Australia, Australian Regenerative Medicine Institute and Faculty of IT, Monash University, Clayton, Victoria, Australia

Le Luo

Affiliation Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Jacob K. White

Affiliations Computational Systems Biology Programme, Singapore-MIT Alliance, Singapore, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Marie-Véronique Clément

bchmvc@nus.edu.sg (MVC); lisa.tucker-kellogg@duke-nus.edu.sg (LTK)

Affiliations Systems Biology Institute (SBI), Clayton, Victoria, Australia, Graduate School of Integrative Sciences and Engineering, National University of Singapore, Singapore

Lisa Tucker-Kellogg

bchmvc@nus.edu.sg (MVC); lisa.tucker-kellogg@duke-nus.edu.sg (LTK)

Affiliations Computational Systems Biology Programme, Singapore-MIT Alliance, Singapore, Duke-NUS Graduate Medical School Singapore, National University of Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Wrote the paper: THN LTK. Provided the question that initiated the study: MVC. Constructed the models: THN LTK. Performed simulations, calibrations, and analyses: THN. Performed Western blots: LL. Measured PIP3: LL THN. Edited the submission: MVC JKW LL.