Biofilm Formation Mechanisms of Pseudomonas aeruginosa Predicted via Genome-Scale Kinetic Models of Bacterial Metabolism

Francisco G. Vital-Lopez; Jaques Reifman; Anders Wallqvist

doi:10.1371/journal.pcbi.1004452

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Open Access

Peer-reviewed

Research Article

Biofilm Formation Mechanisms of Pseudomonas aeruginosa Predicted via Genome-Scale Kinetic Models of Bacterial Metabolism

Francisco G. Vital-Lopez,

Affiliation Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America
⨯
Jaques Reifman ,

* E-mail: jaques.reifman.civ@mail.mil

Affiliation Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America
⨯
Anders Wallqvist

Affiliation Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America
⨯

Biofilm Formation Mechanisms of Pseudomonas aeruginosa Predicted via Genome-Scale Kinetic Models of Bacterial Metabolism

Francisco G. Vital-Lopez,
Jaques Reifman,
Anders Wallqvist

Published: October 2, 2015
https://doi.org/10.1371/journal.pcbi.1004452

About the Authors

Francisco G. Vital-Lopez

Affiliation Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America

Jaques Reifman

* E-mail: jaques.reifman.civ@mail.mil

Anders Wallqvist

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FGVL JR AW. Performed the experiments: FGVL. Analyzed the data: FGVL. Contributed reagents/materials/analysis tools: FGVL. Wrote the paper: FGVL AW JR. Performed the computational implementations: FGVL.

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Bacterial biofilms
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Gene expression
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Metabolites
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Pseudomonas aeruginosa
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Biofilm culture
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Metabolic pathways
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Metabolic networks
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Drug metabolism
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